SkinMedica
TNS Advanced+ Serum
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The most clinically referenced physician-dispensed growth factor + peptide serum; SkinMedica's flagship product with extensive dermatologist recommendations and independent peer-reviewed publications
Community Rating
Derm Mentions
112
Concentration
undisclosed (proprietary growth factor complex)
Peptides in this product
Anti-aging collagen stimulator widely used in anti-aging serums. One of the most well-studied cosmetic peptides with a strong track record for reducing fine lines.
A collagen-boosting signal peptide most often paired with Palmitoyl Tetrapeptide-7 to form the Matrixyl 3000 complex. Popular in anti-aging formulations aimed at mature or sensitive skin.
One of the most researched peptides in cosmetic science. Naturally occurring in human plasma, GHK-Cu declines with age and is involved in wound healing, collagen synthesis, and potentially hair growth.
Other key ingredients
Pros
- ✓Contains a real human fibroblast-derived growth factor complex (TNS-MR) — clinically differentiated
- ✓Extensive peer-reviewed publication history from independent researchers
- ✓Very widely recommended by board-certified dermatologists and plastic surgeons for post-procedure care
- ✓Dual-chamber packaging keeps the active formula stable until point of use
Cons
- ✗Extremely high price point — the most expensive product on this list by a substantial margin
- ✗Human fibroblast conditioned media raises ethical and sourcing questions for some consumers
- ✗Not fragrance-free — unsuitable for the most sensitive or reactive skin types
- ✗Requires physician or authorised medi-spa purchase in most channels
Best for skin type
all skin types; particularly aging and post-procedure skin
Similar products
Best-value multi-peptide serum; stacks Matrixyl, Argireline, and multiple supporting peptides in one affordable formula
Concentrated multi-peptide booster designed to be mixed into any existing moisturiser or serum for a customisable dose of anti-aging peptides
One of the highest disclosed concentrations of GHK-Cu available in a retail product; formulated specifically around copper peptide stability and bioavailability
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Last verified: 2025-03-01
Medical Disclaimer
The information on this site is for educational and informational purposes only. It is not intended as medical advice and should not be used to diagnose, treat, or prevent any condition. Always consult with a qualified healthcare professional before starting any new supplement, peptide, or treatment protocol.