Guidesto Peptides

SkinMedica

TNS Advanced+ Serum

$295.0028.4g($10.39/g)Serum

The most clinically referenced physician-dispensed growth factor + peptide serum; SkinMedica's flagship product with extensive dermatologist recommendations and independent peer-reviewed publications

Community Rating

4.6★/ 5.0

Derm Mentions

112

Concentration

undisclosed (proprietary growth factor complex)

Peptides in this product

Matrixyl

Anti-aging collagen stimulator widely used in anti-aging serums. One of the most well-studied cosmetic peptides with a strong track record for reducing fine lines.

Well-Studied
Palmitoyl Tripeptide-1

A collagen-boosting signal peptide most often paired with Palmitoyl Tetrapeptide-7 to form the Matrixyl 3000 complex. Popular in anti-aging formulations aimed at mature or sensitive skin.

Emerging Research
GHK-Cu

One of the most researched peptides in cosmetic science. Naturally occurring in human plasma, GHK-Cu declines with age and is involved in wound healing, collagen synthesis, and potentially hair growth.

Well-Studied

Other key ingredients

TNS-MR (Human Fibroblast Conditioned Media — Growth Factor Complex)APS Corrective Complex (RejuvenaTING: Palmitoyl Tripeptide-38; RejuvenaTED: Niacinamide, Ribose, Adenosine)NiacinamideAdenosineAntioxidant blend (Vitamin C, E, Ferulic Acid)

Pros

  • ✓Contains a real human fibroblast-derived growth factor complex (TNS-MR) — clinically differentiated
  • ✓Extensive peer-reviewed publication history from independent researchers
  • ✓Very widely recommended by board-certified dermatologists and plastic surgeons for post-procedure care
  • ✓Dual-chamber packaging keeps the active formula stable until point of use

Cons

  • ✗Extremely high price point — the most expensive product on this list by a substantial margin
  • ✗Human fibroblast conditioned media raises ethical and sourcing questions for some consumers
  • ✗Not fragrance-free — unsuitable for the most sensitive or reactive skin types
  • ✗Requires physician or authorised medi-spa purchase in most channels

Best for skin type

all skin types; particularly aging and post-procedure skin

Last verified: 2025-03-01

Medical Disclaimer

The information on this site is for educational and informational purposes only. It is not intended as medical advice and should not be used to diagnose, treat, or prevent any condition. Always consult with a qualified healthcare professional before starting any new supplement, peptide, or treatment protocol.