Peter Thomas Roth
Peptide 21 Wrinkle Resist Serum
Broad-spectrum 21-peptide complex covering signal, carrier, and neurotransmitter-inhibiting peptide classes in one mid-range serum
Community Rating
Derm Mentions
17
Concentration
undisclosed (21-peptide complex)
Peptides in this product
Anti-aging collagen stimulator widely used in anti-aging serums. One of the most well-studied cosmetic peptides with a strong track record for reducing fine lines.
"Botox in a bottle" claims surround this muscle-relaxing peptide. Marketed for expression lines, though its real-world effect is significantly more modest than injectable neurotoxins.
A collagen-boosting signal peptide most often paired with Palmitoyl Tetrapeptide-7 to form the Matrixyl 3000 complex. Popular in anti-aging formulations aimed at mature or sensitive skin.
An anti-inflammatory signal peptide most commonly found paired with Palmitoyl Tripeptide-1 in the Matrixyl 3000 complex. While Palmitoyl Tripeptide-1 stimulates collagen production, Tetrapeptide-7 works to reduce inflammation and skin damage from UV exposure.
Other key ingredients
Pros
- ✓One of the most peptide-diverse retail formulas, covering multiple peptide classes
- ✓Includes complementary active ingredients (niacinamide, HA) rather than peptides alone
- ✓Fragrance-free and non-comedogenic formulation
- ✓Reasonably priced for the peptide breadth offered
Cons
- ✗Proprietary blend means individual peptide concentrations are completely undisclosed
- ✗With 21 ingredients in the complex, many are likely present at trace amounts
- ✗Limited independent clinical data specific to this exact formulation
- ✗Premium brand marketing may outpace the actual ingredient dosing
Best for skin type
all skin types
Last verified: 2025-03-01
Medical Disclaimer
The information on this site is for educational and informational purposes only. It is not intended as medical advice and should not be used to diagnose, treat, or prevent any condition. Always consult with a qualified healthcare professional before starting any new supplement, peptide, or treatment protocol.