Guidesto Peptides

iS Clinical

Pro-Heal Serum Advance+

$158.0030ml($5.27/ml)Serum

Professional-grade vitamin C + retinol + GHK-Cu combination serum; one of the few products deliberately combining these three actives with stabilisation chemistry to prevent copper-ascorbic acid destabilisation

Community Rating

4.5★/ 5.0

Derm Mentions

47

Concentration

15% L-Ascorbic Acid; 0.5% Retinol; GHK-Cu concentration undisclosed

Peptides in this product

GHK-Cu

One of the most researched peptides in cosmetic science. Naturally occurring in human plasma, GHK-Cu declines with age and is involved in wound healing, collagen synthesis, and potentially hair growth.

Well-Studied

Other key ingredients

L-Ascorbic Acid (Vitamin C) 15%Copper Tripeptide-1 (GHK-Cu)Retinol 0.5%Olive Leaf ExtractCentella Asiatica Extract

Pros

  • ✓Combines three well-evidenced actives (vitamin C, retinol, GHK-Cu) in a single stable formula
  • ✓Widely used and recommended in professional aesthetic practice and dermatology clinics
  • ✓Research-grade formulation quality with evidence of photodamage, hyperpigmentation, and acne improvement
  • ✓Suitable for sensitive skin including rosacea-prone skin due to the stabilised, low-irritant formula

Cons

  • ✗High price per ml for a vitamin C-forward serum when compared to standalone L-ascorbic acid serums
  • ✗GHK-Cu concentration is undisclosed — notable given that copper and ascorbic acid can interact
  • ✗Retinol content means this is not appropriate for use during pregnancy
  • ✗Requires gradual introduction for skin not accustomed to combined vitamin C and retinol actives

Best for skin type

all skin types; particularly beneficial for sensitive, blemish-prone, or post-procedure skin

Last verified: 2025-03-01

Medical Disclaimer

The information on this site is for educational and informational purposes only. It is not intended as medical advice and should not be used to diagnose, treat, or prevent any condition. Always consult with a qualified healthcare professional before starting any new supplement, peptide, or treatment protocol.