Palmitoyl Tetrapeptide-7
SkincareAlso known as: Palmitoyl Tetrapeptide-3, Pal-GQPR, Rigin
Emerging ResearchWhat is Palmitoyl Tetrapeptide-7?
An anti-inflammatory signal peptide most commonly found paired with Palmitoyl Tripeptide-1 in the Matrixyl 3000 complex. While Palmitoyl Tripeptide-1 stimulates collagen production, Tetrapeptide-7 works to reduce inflammation and skin damage from UV exposure.
How it works
Reduces the production of interleukin-6 (IL-6), a pro-inflammatory cytokine that increases with age and UV exposure. By suppressing chronic low-grade inflammation (inflammaging), it helps protect existing collagen and elastin from inflammatory degradation.
What marketers claim
- ▸eliminates all signs of aging
- ▸replaces anti-inflammatory medications
- ▸instant skin rejuvenation
- ▸works as a standalone miracle ingredient
What evidence supports
- ✓demonstrated IL-6 suppression in in vitro studies
- ✓shown to reduce inflammation-related skin damage in combination studies
- ✓synergistic anti-aging effects when combined with Palmitoyl Tripeptide-1 (Matrixyl 3000)
- ✓generally well-tolerated in cosmetic formulations
Best for
Safety notes & concerns
- ⚠almost always studied in combination with Palmitoyl Tripeptide-1, making standalone efficacy hard to assess
- ⚠limited independent clinical data on the peptide alone
- ⚠results require consistent long-term use
- ⚠efficacy is formulation-dependent — stability in the product matters
Pairs well with
Use caution with
Products containing Palmitoyl Tetrapeptide-7
The Ordinary
Buffet
Best-value multi-peptide serum; stacks Matrixyl, Argireline, and multiple supporting peptides in one affordable formula
Drunk Elephant
Protini Polypeptide Cream
Premium signal peptide moisturiser beloved by dermatologists for its clean formulation and results in mature and sensitive skin
Paula's Choice
Peptide Booster
Concentrated multi-peptide booster designed to be mixed into any existing moisturiser or serum for a customisable dose of anti-aging peptides
Peter Thomas Roth
Peptide 21 Wrinkle Resist Serum
Broad-spectrum 21-peptide complex covering signal, carrier, and neurotransmitter-inhibiting peptide classes in one mid-range serum
Last updated: 2025-03-21
Medical Disclaimer
The information on this site is for educational and informational purposes only. It is not intended as medical advice and should not be used to diagnose, treat, or prevent any condition. Always consult with a qualified healthcare professional before starting any new supplement, peptide, or treatment protocol.